01541 [upload 2017] Burger's Medicinal Chemistry And Drug Discovery [vol 2 Drug Discovery And Deve...

This is Volume 6: Nervous System Agents, of Burger′s Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Alzheimer′s Disease: Search for Therapeutics, Cognition Enhancers and Drugs to Treat Eating and Body Weight Disorders.

This is Volume 4: Autocoids, Diagnostics, and Drugs from New Biology, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition.

This book contains an overview focusing on the research area of enzyme inhibitors, molecular aspects of drug metabolism, organic synthesis, prodrug synthesis, in silico studies and chemical compounds used in relevant approaches. The book deals with basic issues and some of the recent developments in medicinal chemistry and drug design. Particular emphasis is devoted to both theoretical and experimental aspect of modern drug design. The primary target audience for the book includes students, researchers, biologists, chemists, chemical engineers and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in chemistry, protein biochemistry, enzymology, molecular biology and genetics many of which are active in biochemical and biomedical research.

Presents semi-empirical, hybrid, and quantum chemical methods and explores reactivity, molecular, and quantum-chemical descriptors in QSAR. Views pharmacophore discovery and the use of 3D pharmacophore models in 3D database searching. Studies vibrational circular dichroism spectroscopy for the sterochemical characterization of chiral molecules.