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This volume consists of papers presented at the Variational Analysis and Aerospace Engineering Workshop II held in Erice, Italy in September 2010 at the International School of Mathematics "Guido Stampacchia". The workshop provided a platform for aerospace engineers and mathematicians (from universities, research centers and industry) to discuss the advanced problems requiring an extensive application of mathematics. The presentations were dedicated to the most advanced subjects in engineering and, in particular to computational fluid dynamics methods, introduction of new materials, optimization in aerodynamics, structural optimization, space missions, flight mechanics, control theory and optimization, variational methods and applications, and so on.