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The Renaissance, scholars have long argued, was a period beset by the loss of philosophical certainty. In Possible Knowledge, Debapriya Sarkar argues for the pivotal role of literature―what early moderns termed poesie―in the dynamic intellectual culture of this era of profound incertitude. Revealing how problems of epistemology are inextricable from questions of literary form, Sarkar offers a defense of poiesis, or literary making, as a vital philosophical endeavor.