Axicabtagene Ciloleucel Car T Cell Therapy in Refractory Large B Cell Lymphoma

Editors: Haipeng Shao

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. The book examines the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases.

The feature-length film about a revolutionary treatment for leukaemia did justice to the extraordinary science and the moving stories of the patients involved. Martin Pule spent his childhood dismantling radios, computers and any other devices he came across, reassembling them in alternative ways and pressing them into new services. Even allowing for childish curiosity, it speaks to a different way of conceptualising the world – as a miscellany of parts, only temporarily constituted in their current forms. Most of us are just pleased to come across a device already disposed to work.

An intimate, feature-length documentary following two patients through groundbreaking ‘first in-human’ trials for CAR T-cell therapy, a treatment described as the beginning of the end of cancer. Not allowed to meet and separated by two floors of a hospital, 53-year-old Graham and 18-year old-Mahmoud are nevertheless bound together by their commitment to the treatment and their faith in the science. Terminally ill, the trial represents their only option. How do their ages and life experiences affect their physical and emotional response?