Endocrine Therapy of Breast Cancer VI

book, whose goal is to comprehensively review in ten During the past 30 years we have witnessed the emer­ chapters the fundamental knowledge on breast can­ gence of new disciplines whose contribution to the understanding of the biology of breast cancer have cer. The opening chapter links epidemiology, influ­ been enormous. Advances in the field of steroid hor­ ence of geographic and environmental exposures on mone nuclear receptors, which control the expression cancer incidence to the development of the organ and of genetic programs involved in cellular processes its role in cancer initiation. Central to this approach that are essential for normal and aberrant cell is the endocrine control of breast development, the growth, have been major contributors to the therapy relationship of cell proliferation with the presence of and prevention of hormone-dependent cancers.

This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer.

The Third Breast Cancer Working Conference of the Breast Cancer Cooperative Group of the European Organization for Research on Treatment of Cancer, to be held in Amsterdam on April 27-29, 1983, was the principle motive for writing this book. It was feh that a short review of the main pathogenetic conceptions and therapeutic principles which have presented themselves with regard to mammary cancer in the Course of Western history , might help to draw a more complete picture of where we stand today.

This book presents expert opinions on a variety of key topics related to the management of breast cancer, with a focus on the implications of recent advances and research findings for clinical practice. It also explores the controversy regarding mammography screening and reviews the contribution of new imaging modalities.