Physiologically Based Pharmacokinetic (pbpk)modeling And Simulations: Principles

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.

Physical and chemical properties of simple and complex liquids or mixtures play an important role in industrial manufacturing processes. Liquids serve as the reaction solvent media in the preparation of new chemical compounds, as an extraction solvent in the purification of synthesized materials, as a solubilizing agent in both pharmaceutical formulations and personal healthcare products, as a fuel to meet industrial heat demand, and as a coolant to maintain a desired reaction temperature. Special emphasis was given to studies that reported the latest technical and theoretical results concerning the properties and processes of industrial significance.

The Art of Asking Essential Questions shines a light on an underappreciated but vital skill set that lies at the root of all learning and success. Not only do questions help us gain knowledge on a topic, but they also allow us to dispel erroneous or deceptive information, uncover assumptions and motivations, draw accurate conclusions, and make sustainable plans.

This book includes more than twenty computer games and simulations for use in teacher training. Each of these simulations is innovative and presents an opportunity for pre-service teachers to have hands-on experience in an area of need prior to teaching in the classroom. Information on the simulation origins, including theoretical underpinnings, goals, characteristics, relevant research/program evaluation results, discussion of benefits and limitations as well as dissemination, recommended use, scope of practice, etc.