Rational Mechanics

Tunnellingisanexcitingandrapidlyevolvingtechnology.Pioneeringprocesses are commonplace and innovative thinking continues to rewrite the rules. In civil engineering, tunnelling is one of the few areas where new horizons are constantly being discovered. But for the profession to reach its full potential, tunnelling needs to be more accessible to those talented engineers in search of new challenges and keen to make lasting contributions to society.

This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows.

This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows.

This book systematically introduces readers to computational granular mechanics and its relative engineering applications. Part I describes the fundamentals, such as the generation of irregular particle shapes, contact models, macro-micro theory, DEM-FEM coupling, and solid-fluid coupling of granular materials.

While no idea is entirely new, it is pretty agreed that the 1958 seminal study of the creep rupture by Lazar M. Kachanov marks the birthday ofwhat we today know as continuum damage mechanics. In thefollowing years the interest in this new branch of continuum mechanics grew beyond the fondest hopes as it became plainly obvious that damage mechanics represents a rational framework for the treatment of a wide range of brittle phenomena.

This book systematically introduces readers to computational granular mechanics and its relative engineering applications. Part I describes the fundamentals, such as the generation of irregular particle shapes, contact models, macro-micro theory, DEM-FEM coupling, and solid-fluid coupling of granular materials.

This book systematically introduces readers to computational granular mechanics and its relative engineering applications. Part I describes the fundamentals, such as the generation of irregular particle shapes, contact models, macro-micro theory, DEM-FEM coupling, and solid-fluid coupling of granular materials.