Synthesis of Best Seller Drugs

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When attempting to provide an overview of a big story – one that encompasses both the myriad achievements of its subjects over a span of several decades and the impacts of those achievements – you can take two routes. There’s the “just the facts” approach, where you list off the people, places, and things that populate the tale, and then there’s another road that winds through the hows and whys behind the names and numbers. Looking at the story of Canadian indie rock institution Sloan, the temptation to look through both lenses is strong.

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC).

As the best-selling author of Exodus, Mila 18, QB VII, and Trinity, Leon Uris blazed a path to celebrity with books that readers could not put down. Uris's thirteen novels sold millions of copies, spent months on the best-seller lists, appeared in fifty languages, and have been adapted into equally popular movies and TV miniseries. Few other writers equaled Uris's fame in the mid-twentieth century. His success fueled the rise of mass-market paperbacks, movie tie-ins, and celebrity author tours. Beloved by the public, Uris was, not surprisingly, dismissed by literary critics. Until now, his own life—as full of drama as his fiction—has never been the subject of a book.