Allgemeine Strahlentherapie Maligner Tumoren Radiation Therapy of Malignant Tumours General Considerations

This practical guide, now in a revised and updated second edition with more clinical cases for different stages, is designed as a concise reference on the delineation of target volumes in radiation oncology. Clear guidance is provided on simulation, setup, and field design for all of the malignancies commonly encountered by practicing radiation oncologists, and slice-by-slice examples are provided for different clinical stages and scenarios. The new edition of this book fully covers modern radiotherapy field design, with inclusion of guidelines on immobilization and simulation for 3D-conformal radiotherapy, intensity-modulated radiation therapy, and stereotactic body radiation therapy. Target Volume Delineation and Field Setup: A Practical Guide for Conformal and Intensity-Modulated Radiation Therapy is written by leading radiation oncologists who provide their expert opinions on all relevant aspects.

This book provides updated knowledge on esophageal cancer diagnosis and treatment options. Esophageal cancer has become one of the cancers that can be detected early with the widespread use of endoscopy. Combinations of chemotherapy, radiotherapy and surgical treatment are used in the treatment. Depending on the planning of the surgery, operation is performed in two or three anatomical areas such as abdomen, thorax or cervical region. A good preoperative evaluation and postoperative follow-up and treatment are very important. In the book each stage of the disease is explained by different branches with a multidisciplinary approach. The book addresses professionals in oncology, radiology and surgery.

This third edition provides new and updated chapters on gene therapeutic strategies of cancer. Chapters guide readers through suicide and oncolytic gene therapy, gene replacement and gene suppression therapy, vector development and refinement, immunogene therapy, TCR and CAR engineering, tumor vaccination using DNA or RNA vaccines, and antitumoral immune stimulation at different levels. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

The thesis tackles two distinct problems of great interest in gravitational mechanics — one relativistic and one Newtonian. The relativistic one is concerned with the "first law of binary mechanics", a remarkably simple variational relation that plays a crucial role in the modern understanding of the gravitational two-body problem, thereby contributing to the effort to detect gravitational-wave signals from binary systems of black holes and neutron stars. The work reported in the thesis provides a mathematically elegant extension of previous results to compact objects that carry spin angular momentum and quadrupolar deformations, which more accurately represent astrophysical bodies than mere point particles.