Infliximab And Methotrexate in The Treatment of Rheumatoid Arthritis

This volume is dedicated to the pathogenesis of rheumatoid arthritis (RA). MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

This book reviews all aspects of major depressive disorder (MDD), casting light on its neurobiological underpinnings and describing the most recent advances in management. The book is divided into four sections, the first of which discusses MDD from a network science perspective, highlighting the alterations in functional and structural connectivity and presenting insights achieved through resting state functional MRI and the development of neuroimaging-based biomarkers. The second section examines important diagnostic and neurobiological issues, while the third considers the currently available specific treatments for MDD, including biofeedback, neurofeedback, cognitive behavioral therapy, acceptance and commitment therapy, neuromodulation therapy, psychodynamic therapy, and complementary and alternative medicine. A concluding section is devoted to promising emerging treatments, from novel psychopharmacological therapies through to virtual reality treatment, immunotherapy, biomarker-guided tailored therapy, and more. Written by leading experts from across the world, the book will be an excellent source of information for both researchers and practitioners.

This book explores the interplay between liberalism and imperialism in Second Empire France. By examining the political dimension of imperial expansion and the power of words in shaping public opinion, it sheds light on the ways in which liberal ideas developed in the nineteenth century. In contrast to Britain, French imperialism in the third quarter of the nineteenth century was fostered by a Bonapartist regime that liberals needed to fight in order to build their own political brand. The author argues that the 1860s were not so much a period of ‘liberal empire’ in France as has traditionally been suggested, since liberals were in fact more conveyers of political change rather than supporters of the regime.

This book analyses the economic history of the company and entrepreneurship in Spain from the 15th century to the present. It evaluates the economic theory, the formation of the figure of the entrepreneur, as well as the structure of the companies.

This book presents essays by eminent scholars from across the history of medicine, early science and European history, including those expert on the history of the book. The volume honors Professor Nancy Siraisi and reflects the impact that Siraisi's scholarship has had on a range of fields.