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A car delivery driver, Kowalski (Barry Newman), arrives in Denver, Colorado late Friday night with a black Chrysler Imperial.[Note 2] The delivery service clerk, Sandy (Karl Swenson), urges him to get some rest, but Kowalski insists on getting started with his next assignment to deliver a white 1970 Dodge Challenger R/T 440 Magnum to San Francisco by Monday. Before leaving Denver, Kowalski pulls into a biker bar parking lot around midnight to buy Benzedrine pills to stay awake for the long drive ahead. He bets his dealer, Jake (Lee Weaver), that he will get to San Francisco by 3:00 pm Saturday, even though the delivery is not due until Monday.

À Shenzhen, aux portes de Hong Kong, l’entreprise privée BGI (Beijing Genomics Institute) est le plus grand centre de recherche génétique au monde, tant en personnel (quelque quatre mille salariés) qu’en moyens techniques (plus de cent cinquante séquenceurs d’ADN aujourd’hui). Son objectif, pleinement assumé, et soutenu massivement par le gouvernement : se hisser à la pointe de la recherche mondiale sur le génome pour faire bénéficier le public, tout au moins celui qui est solvable, de ses progrès…

Charles "Charly" Matteï è un ex esponente della criminalità organizzata marsigliese, ora redento. L'uomo subisce un agguato in un parcheggio, venendo colpito da ventidue colpi di armi da fuoco, ma miracolosamente sopravvive. Uscito dall'ospedale, scopre la verità sulla faccenda, ma decide di non cercare vendetta per non rientrare nel giro.