Journal of Cachexia,sarcopenia Muscle

With the advent of enzyme histochemistry, which this field and simplistic theories will be expanded or revealed hitherto unseen pathological differences discarded. between muscle disorders, muscle biopsy assumed Diseased muscle cells, as any other cell type, show an important diagnostic role.

Biophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads–especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling.

Daniel Defoe's A Journal of the Plague Year has taken on a new relevance with the advent of the Covid-19 pandemic. Through an exploration of two chronologically distant societies in crisis, this study compares the attitudes, beliefs, and conduct of the public portrayed in the book and those in our own embattled Covid era. There are interesting similarities to note, with equivalents to the Covid-deniers and the anti-vaxxers to be found in Defoe's bleak vision of London in the 1660s as it descends into a state of chaos. JPY offers us some uncomfortable truths about human nature that resonate strongly in our own times, revealing how responding to a pandemic can bring out both the best and the worst in our character as we face up to a world where the old certainties no longer seem to apply. Pandemics expose the fault-lines in ideology, putting the social contract at risk - the question they pose is whether we can continue to rely on our current socio-political set-up or whether it requires a radical rethink. There is a pressing need for more debate on this issue, and this project is designed to make a case for that.

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