A young nurse, Alma, is put in charge of Elisabeth Vogler: an actress who is seemingly healthy in all respects, but will not talk. As they spend time together, Alma speaks to Elisabeth constantly, never receiving any answer. Alma eventually confesses her secrets to a seemingly sympathetic Elisabeth and finds that her own personality is being submerged into Elisabeth's persona.
Persona is difficult to characterize in simple terms, but it may be helpful to describe this complex film as being an exploration of identity that combines elements of drama, visual poetry, and modern psychology. The central story revolves around a young nurse named Alma (Bibi Andersson) and her patient, a well-known actress named Elisabet Vogler (Liv Ullmann). Elisabet has stopped speaking, and the attending psychiatrist treats the actress by sending her to an isolated seaside cottage under Alma's care. There the nurse, who must do all the talking for both women, becomes a little enamored of the actress. One evening Alma tells Elisabet about some exhilarating sexual experiences she once had and their unpleasant aftermath. Soon after sharing this confidence, the nurse reads a letter Elisabet has written and is shocked to learn that the actress thinks of her as an amusing study. The relationship between the women becomes tense, and they wound each other.