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This book convenes peer-reviewed, selected papers presented at the Tenth International Conference New Trends in the Applications of Differential Equations in Sciences (NTADES) held in Saints Constantine and Helena, Bulgaria, July 17–20, 2023. Contributions are devoted to many applications of differential equations in different fields of science. A number of phenomena in nature (physics, chemistry, biology) and in society (economics) result in problems leading to the study of linear and nonlinear differential equations, stochastic equations, statistics, analysis, numerical analysis, optimization, and more. The main topics are presented in the five parts of the book - applications in mathematical physics, mathematical biology, financial mathematics, neuroscience, and fractional analysis.