This two-part series explains, in easily accessible terms, the discovery of the infinitely small particles-the quarks and neutrinos, muons and bosons-that make up everything in nature, from microbes to stars. It covers the nature and functions of the individual particles, and their roles in the Standard Model of particle physics (a theory that is as much a masterpiece in science as Shakespeare's works are in literature). The lectures also trace the history of particle physics as a science, and the dedicated scientists and complex technology that have made this branch of physics so profoundly productive and important.