Asthma

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling.

Asthma is a respiratory condition marked by spasms, swelling, and excess mucus production in the bronchial passages of the lungs. This triggers coughing, wheezing, chest tightness, and shortness of breath. While asthma can usually be managed with medications and avoidance of certain triggers, it's a serious—potentially deadly—chronic disease.

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