Checkpoint Responses in Cancer Therapy

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets.

This book provides an up-to-date overview of advances in the field of immuno-oncology. The book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects.

by Paolo A. Ascierto (Editor), David F. Stroncek (Editor), Ena Wang (Editor)
Summarizes and discusses current advancements in T cell-based anticancer immunotherapy
Comprehensively covers T cell biology, including T cell lineage differentiation stages, mechanisms of anergy and activation, exhaustion, senescence, stemness, and strategies of deregulation for therapeutic development
Explores novel approach of hematopoietic stem cell transplantation as a method of immune therapy for cancer