Clinical Tuberculosis

This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs.

This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology.

This concise, clinically focused handbook offers a complete overview of tuberculosis and reviews the latest guidelines, treatment options, clinical trials and management of this disease. Handbook of Tuberculosis is a well-rounded book written by renowned researchers at the Johns Hopkins Center for Tuberculosis Research. The easily accessible text offers infectious disease specialists, pulmonologists, and other healthcare workers an excellent quick reference tool, with full color tables and figures enhancing the text further.

Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”.