Mathematical Biology

This publication is a Special Issue of the journal Axioms entitled “Calculus of Variations, Optimal Control and Mathematical Biology: A Themed Issue Dedicated to Professor Delfim F. M. Torres on the Occasion of His 50th birthday”. This Special Issue is dedicated to Professor Delfim F. M. Torres on his 50th birthday, as a recognition of his significant contributions to Mathematics, in particular regarding the calculus of variations, optimal control, and mathematical biology. Professor Torres is a distinguished University Professor, a highly cited researcher in Mathematics (in the top 1% for Mathematics in the Web of Science in 2015, 2016, 2017, and 2019), and a lifetime member of the American Mathematical Society.

It has been over a decade since the release first edition of the now classic original edition of Murray's Mathematical Biology. Since then mathematical biology and medicine has grown at an astonishing rate and has established itself as a distinct discipline. Mathematical modelling is now being applied in every major discipline in the biomedical sciences. Though the field has become increasingly large and specialized, this book remains important as a text that introduces some of the exciting problems which arise in the biomedical sciences and gives some indication of the wide spectrum of questions that modelling can address.

This book developed from classes in mathematical biology taught by the authors over several years at the Technische Universität München. The main themes are modeling principles, mathematical principles for the analysis of these models and model-based analysis of data. The key topics of modern biomathematics are covered: ecology, epidemiology, biochemistry, regulatory networks, neuronal networks and population genetics. A variety of mathematical methods are introduced, ranging from ordinary and partial differential equations to stochastic graph theory and branching processes. A special emphasis is placed on the interplay between stochastic and deterministic models.

Foreword The modern developments in mathematical biology took place roughly between 1920 and 1940, a period now referred to as the "Golden Age of Theoretical Biology". The eminent Italian mathematician Vito Volterra played a decisive and widely acknowledged role in these developments. Volterra's interest in the application of mathematics to the non physical sciences, and to biology and economics in particular, dates back to the turn of the century and was expressed in his inaugural address at the University of Rome for the academic year 1900/01 (VOLTERRA 1901).

Foreword The modern developments in mathematical biology took place roughly between 1920 and 1940, a period now referred to as the "Golden Age of Theoretical Biology". The eminent Italian mathematician Vito Volterra played a decisive and widely acknowledged role in these developments. Volterra's interest in the application of mathematics to the non physical sciences, and to biology and economics in particular, dates back to the turn of the century and was expressed in his inaugural address at the University of Rome for the academic year 1900/01 (VOLTERRA 1901).