Proteinase Inhibitors

This book aims at presenting an overview of the current knowledge of cystatins and molecles of the cystatin superfamily, their structure, physio-and pathological function as well as the direction that research is currently aiming for in developing therapeutic treatments based on cysteine proteinases and related molecules.

Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades.

This book contains an overview focusing on the research area of enzyme inhibitors, molecular aspects of drug metabolism, organic synthesis, prodrug synthesis, in silico studies and chemical compounds used in relevant approaches. The book deals with basic issues and some of the recent developments in medicinal chemistry and drug design. Particular emphasis is devoted to both theoretical and experimental aspect of modern drug design. The primary target audience for the book includes students, researchers, biologists, chemists, chemical engineers and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in chemistry, protein biochemistry, enzymology, molecular biology and genetics many of which are active in biochemical and biomedical research.