Spectroscopic Methods in Organic Chemistry

This book is a well-established guide to the interpretation of the mass, ultraviolet, infrared and nuclear magnetic resonance spectra of organic compounds. It is designed for students of organic chemistry taking a course in the application of these techniques to structure determination. The text also remains useful as a source of data for organic chemists to keep on their desks throughout their career.

by Reinhard W. Hoffmann (Author)
The structures of many natural products are given in standard textbooks on organic chemistry as 'established facts'. Yet for those natural products whose structures were determined between 1860 and 1960 by classical chemical methods, the lines of evidence are frequently buried under any number of investigations that led to dead ends and to revised structure assignments.

Gain confidence in NMR (1H and 13C), IR, and MS with guided practice problems.

Gain confidence in NMR (1H and 13C), IR, and MS with guided practice problems.

This volume presents three chapters discussing a range of topics. Chapter 1 deals with the development of efficient methods for compound dereplication that have been critical in the re-emergence of research on natural products as a source of new drug leads. It describes the main methods of dereplication, which rely on the combined use of large natural product databases and spectral libraries, alongside the information obtained from chromatographic, UV-Vis, MS, and NMR spectroscopic analyses of the samples of interest. Chapter 2 describes 989 plant natural products and their ecological functions in plant-herbivore, plant-microorganism, and plant-plant interactions. These compounds include alkaloids, phenols, terpenoids, and other structural types. The information presented should provide the basis for in-depth research on these plant natural products and their natural functions, and also for their further development and utilization. Chapter 3 focuses on lichens, with each constituting a symbiotic association composed of a primary mycobiont and one or more photobionts living mutualistically. Covered are lichens and their bionts, taxonomic identification, and their chemical constituents as exemplified by what is found in lichen biomes, especially those endemic to North America. Extraction and isolation procedures, as well as updates on dereplication methods using mass spectrometric GNPS and NMR spectroscopic spin network fingerprint procedures, and marker-based techniques to identify lichens are discussed. The isolation and structure elucidation of secondary metabolites of an endolichenic Penicillium species that produces bioactive compounds is described in detail.

This volume presents three chapters discussing a range of topics. Chapter 1 deals with the development of efficient methods for compound dereplication that have been critical in the re-emergence of research on natural products as a source of new drug leads. It describes the main methods of dereplication, which rely on the combined use of large natural product databases and spectral libraries, alongside the information obtained from chromatographic, UV-Vis, MS, and NMR spectroscopic analyses of the samples of interest. Chapter 2 describes 989 plant natural products and their ecological functions in plant-herbivore, plant-microorganism, and plant-plant interactions. These compounds include alkaloids, phenols, terpenoids, and other structural types. The information presented should provide the basis for in-depth research on these plant natural products and their natural functions, and also for their further development and utilization. Chapter 3 focuses on lichens, with each constituting a symbiotic association composed of a primary mycobiont and one or more photobionts living mutualistically. Covered are lichens and their bionts, taxonomic identification, and their chemical constituents as exemplified by what is found in lichen biomes, especially those endemic to North America. Extraction and isolation procedures, as well as updates on dereplication methods using mass spectrometric GNPS and NMR spectroscopic spin network fingerprint procedures, and marker-based techniques to identify lichens are discussed. The isolation and structure elucidation of secondary metabolites of an endolichenic Penicillium species that produces bioactive compounds is described in detail.

Gain confidence in NMR (1H and 13C), IR, and MS with guided practice problems.