Pharmacokinetics in Drug Development

This volume delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies.

Clinical Trials, Phase 0, Phase 1, Drug Development, Early-Phase Trials, Microdosing, Drug Safety, Pharmacokinetics,

All the basic concepts of pharmacokinetics (PKs) are described, with an emphasis on understanding what parameters such as bioavailability, volume of distribution and clearance tell us about the behaviour of a particular drug. The use of PKs in both a drug development and a clinical setting are covered.

This thorough book explores some of the most important methods and concepts affecting the quantitative analysis of the transport, targeting, and disposition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism.