Progress in Molecular And Subcellular Biology

This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products’ chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins,

Cell biologists have recently come to understand that asymmetry of division is an important regulatory phenomenon in the fate of a cell. In adult organisms asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to aging.rs.

Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing.

The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA–protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements.

by David Holcman (Author), Zeev Schuss (Author)
Shows how to implement models and numerical methods
Provides the latest techniques in applied mathematics for cellular microdomains
Takes a quantitative approach in cellular biology and open questions (signaling in virus trafficking, growth cone dynamics, DNA breaks, and many others)

Lake Baikal is the oldest, deepest and most voluminous lake on Earth, comprising one fifth of the World’s unfrozen fresh water. It hosts the highest number of endemic animals recorded in any freshwater lake. Until recently it remained enigmatic why such a high diversity evolved in the isolated Lake Baikal. Focusing on the sponges (phylum Porifera) as an example, some answers are provided to fundamental questions on evolutionary forces.