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The productivity in pharmaceutical research and development faces intense pres­ sure. R&D expenditures of the major US and European companies have topped US$ 33 billion in 2003 compared to around US$ 13 billion just a decade ago. At the same time, the number of new drug approvals has dropped from 53 in 1996 to only 35 in 2003. Moreover, the protraction of clinical trials has significantly reduced the effective time of patent protection. The consequences are devastating. Monopoly profits have started to decline and the average costs per new drug have reached a re­ cord level of close to US$ 1 billion today. As a result, any failure of a new sub­ stance in the R&D process can lead to considerable losses, and the risks of introduc­ ing a new drug to the market have grown tremendously. Particularly if a company is highly dependent on just a handful of mega-selling blockbuster drugs, the risks can be even greater. For example, Pfizer generated about 90% of its worldwide revenues in 2002 with just 8 products. Any shortfall of a promising late-stage drug candidate would have left Pfizer with a gaping hole in its product portfolio. In order to deal with these risks, many pharmaceutical companies have started to organize their R&D in partnership. In fact, more than 600 alliances in pharmaceutical R&D are signed every year.

This updated edition retains its introduction to applied fundamental statistics, probability, reliability, and decision theory as these pertain to problems in Civil Engineering. The new edition adds an expanded treatment of systems reliability, Bayesian methods, and spatial variabililty, along with additional example problems throughout. The book provides readers with the tools needed to determine the probability of failure, and when multiplied by the consequences of failure, illustrates how to assess the risk of civil engineering problems.

Master risk management in banks with comprehensive insights into credit, liquidity, and market risk strategies!

Risk Assessment and Compliance Strategies

Risk Assessment and Compliance Strategies

Learn Operational Risk Management (ORM) and Enterprise Risk Management (ERM)

Master risk management in banks with comprehensive insights into credit, liquidity, and market risk strategies!