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The purpose of this clinical transfusion medicine handbook is to take the reader through a variety of clinical problems, each one likely to be encountered in a busy teaching hospital. The reader follows the stream of clinical and laboratory data, developing the ability for critical thinking which leads him/her to diagnosis and appropriate management. The book is a lively illustration of various clinical problems in transfusion medicine, including immune complications, microbiological problems, blood component use, apheresis techniques, and management of complex situations such as multiple trauma, sickle cell crisis, and organ transplantation. Each case is carefully chosen and presented, with incorporated questions, leading the reader towards solution of the problem in a logical and didactic manner