Bone Metastases

Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer.

A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.With the World Health Organization's Decade of Bone and Joint Disease report and the 2004 U.S. Surgeon General's report on bone health and osteoporosis, we are reminded of the prevalence and cost of postmenopausal osteoporosis and fractures, cancer metastases to bone, and a host of endocrine and genetic disorders that have a primary impact on cartilage and bone. (Figure) The Skeleton will not guide the clinician in the management of skeletal disorders. Rather, Massaro and Rogers have assembled a series of review articles on selected topics in skeletal biology that will be most useful to researchers seeking an overview of particular topics or to cross-disciplinary practitioners with an interest in bone biology.

This book, now in its revised and updated third edition, offers a comprehensive overview of the state of the art in orthopedic nuclear medicine, including the impressive recent advances in the field and the diagnosis of under-recognized conditions based on their imaging patterns. The opening chapters acquaint the reader briefly with anatomic, physiologic, pathologic, and technical concepts crucial to a sound understanding of orthopedic nuclear medicine and its utilization in clinical practice. The imaging diagnosis of skeletal infections, trauma, vascular disorders, metabolic and neoplastic bone diseases, soft tissue calcifications, and joint disorders is then explained in detail. New developments in the role of nuclear medicine in the management of bone tumors and particularly, in the diagnosis and treatment of prostate cancer metastases have been added to this new edition. The book is richly illustrated with many newly added figures and illustrations and amply documents the effectiveness of nuclear medicine in diagnosing bone disease. It will prove invaluable to all with an interest in diagnostic and therapeutic orthopedics, including orthopedists, radiologists, rheumatologists, pediatricians, podiatrists, other clinicians, and all nuclear and molecular imaging professionals.

The purpose of this book is to outline the topics that are critical in the dermatological approach to patients with cancer. This purpose will be accomplished by discussing the value of a multidisciplinary approach, and case examples will be used, including some from the Hospital Sírio-Libanês, a pioneering institution in the treatment of cancer. In all, the book will present and discuss the best global evidence for the dermatologic care of patients with cancer, skin cancer, and solid organ- and bone-marrow-transplanted patients.