Cellular Lipid Metabolism

This book deals with a vital topic: metabolism in the cells of the body and various disorders due to its imbalance and/or diseases that disrupt the metabolism of the body.

For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipids into a hydrophobic groove on the distal surface of the protein, forming CD1-lipid complexes that act as ligands for T cell receptors. CD1-reactive T cells with conserved (NK T cells) or diverse T cell receptors possess cytokine secretion and other effector mechanisms that influence many aspects of immune response.

Phospholipids are no longer considered exclusively as the building blocks of biomembranes, but are now regarded to be exceptionally important to cellular signalling.

Peroxisome Proliferator-Activated Receptors (PPARs) are transcription factors that belong to the nuclear hormone receptor superfamily. Nuclear receptors are one of the best described classes of regulatory factors that directly control gene expression. Humans and mice have 48 and 49 nuclear receptors, respectively, which modulate many functions such as reproduction, development, metabolism, and whole body homeostasis. They function as ligand-activated factors, and thus convert signalling by small molecules (hormones, vitamins, fatty acids), which control these processes, into appropriate gene responses.

by David Q -H Wang (Author)

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically.

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically.