Pharmacokinetics

Authors: Macheras, Panos, Iliadis, Athanassios
Updated state-of-the-art information on biopharmaceutic, pharmacokinetic, and pharmacodynamic modeling
New chapters on Bioequivalence and Fractional Pharmacokinetics, contributed by leaders in the field
New sections on time-varying models and interface models
Appeals to both graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology
Covers the theory with specific examples behind all three under the perspective of heterogeneous processes while also treating the current state of the art in applied and theoretical BPP

This volume delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies.

by John E. Murphy (Author)